”Best?” Yes. He is vicious. He’s also creepily calm and intense. I don’t like it. He is so creepy that Ms. Shakespeare and I have been known to quote him just to skeeve the other one out. Ms. Shakespeare, "do you remember our sensuous night beneath the cherry trees?" Mwahahah! Dr. Muraki is the best anime villain in that he is irredeemably evil, overtly predatory and still somehow charismatic and beautiful. So evil! SO EVIL!! Is he human? Is he demon? No one knows. He seems to have no motivation beyond just being evil (and attracted to our hero Asato Tsuzuki)...EVIL! Like a pretty, pretty snake who will tie you up and make sexually suggestive remarks before biting you.
A close second is Light Yagumi of Death Note (yet another Shigigami or Soul Reaper drama) he is irredeemably awful, and the lead character. I like the way Death Note sets up Light as the protagonist only to allow viewers to watch him fall further and further from his first purpose into a narcissistic villain who destroys pretty much everything he once believed in. He’s truly horrible, but he doesn't quite have the creep factor of Dr. Muraki. So despite playing God, betraying everyone he knows, and stacking up one hell of a body count, he gets bumped to number two.
I need to do a Death Note post soon. It is a pretty messed-up series.